Are redox changes a critical switch for mitotic progression?
Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Informa UK Limited
2021
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| Online Access: | https://hdl.handle.net/1721.1/134407.2 |
| _version_ | 1810984105632858112 |
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| author | Lim, Daniel Cham-Chin Joukov, Vladimir Yaffe, Michael B |
| author2 | Center for Precision Cancer Medicine |
| author_facet | Center for Precision Cancer Medicine Lim, Daniel Cham-Chin Joukov, Vladimir Yaffe, Michael B |
| author_sort | Lim, Daniel Cham-Chin |
| collection | MIT |
| description | Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy. |
| first_indexed | 2024-09-23T10:57:08Z |
| format | Article |
| id | mit-1721.1/134407.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:57:08Z |
| publishDate | 2021 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/134407.22021-11-30T15:53:01Z Are redox changes a critical switch for mitotic progression? Lim, Daniel Cham-Chin Joukov, Vladimir Yaffe, Michael B Center for Precision Cancer Medicine Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy. NIH (Grants R01-ES015339, R35-ES028374, R01-GM104047, and R21-ES020466) 2021-11-30T15:53:00Z 2021-10-27T20:04:52Z 2021-11-30T15:53:00Z 2020 2021-08-04T15:14:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134407.2 en 10.1080/23723556.2020.1832419 Molecular and Cellular Oncology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/octet-stream Informa UK Limited Taylor & Francis |
| spellingShingle | Lim, Daniel Cham-Chin Joukov, Vladimir Yaffe, Michael B Are redox changes a critical switch for mitotic progression? |
| title | Are redox changes a critical switch for mitotic progression? |
| title_full | Are redox changes a critical switch for mitotic progression? |
| title_fullStr | Are redox changes a critical switch for mitotic progression? |
| title_full_unstemmed | Are redox changes a critical switch for mitotic progression? |
| title_short | Are redox changes a critical switch for mitotic progression? |
| title_sort | are redox changes a critical switch for mitotic progression |
| url | https://hdl.handle.net/1721.1/134407.2 |
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