BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

© 2020, The Author(s). Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss of this coordination can lead to DNA damage from increased transcription-replication collision events. We report that...

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Bibliographic Details
Main Authors: Lam, Fred C, Kong, Yi Wen, Huang, Qiuying, Vu Han, Tu-Lan, Maffa, Amanda D, Kasper, Ekkehard M, Yaffe, Michael B
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/134408

Internet

https://hdl.handle.net/1721.1/134408

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