Poly(ethylene glycol) with Observable Shedding

A FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off nanoparticles (NPs; see picture). When the NPs were targeted on cancer cell lines, the reducing endosomal environment caused the cleavage of the disulfide bond and the shedding of the PEG layer. © 2010 W...

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Bibliographic Details
Main Authors: Gao, Weiwei, Langer, Robert S, Farokhzad, Omid C
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:English
Published: Wiley 2022
Online Access:https://hdl.handle.net/1721.1/134534.2