Poly(ethylene glycol) with Observable Shedding
A FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off nanoparticles (NPs; see picture). When the NPs were targeted on cancer cell lines, the reducing endosomal environment caused the cleavage of the disulfide bond and the shedding of the PEG layer. © 2010 W...
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| Format: | Article |
| Language: | English |
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Wiley
2021
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| Online Access: | https://hdl.handle.net/1721.1/134534 |
| _version_ | 1826210575991963648 |
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| author | Gao, Weiwei Langer, Robert Farokhzad, Omid C |
| author_facet | Gao, Weiwei Langer, Robert Farokhzad, Omid C |
| author_sort | Gao, Weiwei |
| collection | MIT |
| description | A FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off nanoparticles (NPs; see picture). When the NPs were targeted on cancer cell lines, the reducing endosomal environment caused the cleavage of the disulfide bond and the shedding of the PEG layer. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| first_indexed | 2024-09-23T14:52:10Z |
| format | Article |
| id | mit-1721.1/134534 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:52:10Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1345342021-10-28T03:31:52Z Poly(ethylene glycol) with Observable Shedding Gao, Weiwei Langer, Robert Farokhzad, Omid C A FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off nanoparticles (NPs; see picture). When the NPs were targeted on cancer cell lines, the reducing endosomal environment caused the cleavage of the disulfide bond and the shedding of the PEG layer. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. 2021-10-27T20:05:27Z 2021-10-27T20:05:27Z 2010 2019-09-03T18:46:20Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/134534 Gao, W. W., R. Langer, and O. C. Farokhzad. "Poly(Ethylene Glycol) with Observable Shedding." Angewandte Chemie-International Edition 49 37 (2010): 6567-71. en 10.1002/anie.201001868 Angewandte Chemie - International Edition Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Gao, Weiwei Langer, Robert Farokhzad, Omid C Poly(ethylene glycol) with Observable Shedding |
| title | Poly(ethylene glycol) with Observable Shedding |
| title_full | Poly(ethylene glycol) with Observable Shedding |
| title_fullStr | Poly(ethylene glycol) with Observable Shedding |
| title_full_unstemmed | Poly(ethylene glycol) with Observable Shedding |
| title_short | Poly(ethylene glycol) with Observable Shedding |
| title_sort | poly ethylene glycol with observable shedding |
| url | https://hdl.handle.net/1721.1/134534 |
| work_keys_str_mv | AT gaoweiwei polyethyleneglycolwithobservableshedding AT langerrobert polyethyleneglycolwithobservableshedding AT farokhzadomidc polyethyleneglycolwithobservableshedding |