HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

© 2020, The Author(s). DNA damage contributes to brain aging and neurodegenerative diseases. However, the factors stimulating DNA repair to stave off functional decline remain obscure. We show that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) repair in the brain. HDAC1-deficient mice display...

Full description

Bibliographic Details
Main Authors: Pao, Ping-Chieh, Patnaik, Debasis, Watson, L Ashley, Gao, Fan, Pan, Ling, Wang, Jun, Adaikkan, Chinnakkaruppan, Penney, Jay, Cam, Hugh P, Huang, Wen-Chin, Pantano, Lorena, Lee, Audrey, Nott, Alexi, Phan, Trongha X, Gjoneska, Elizabeta, Elmsaouri, Sara, Haggarty, Stephen J, Tsai, Li-Huei
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/134543

Internet

https://hdl.handle.net/1721.1/134543

Similar Items