Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells

© 2017 Elsevier Ltd Current ISC culture systems face significant challenges such as animal-derived or undefined matrix compositions, batch-to-batch variability (e.g. Matrigel-based organoid culture), and complexity of assaying cell aggregates such as organoids which renders the research and clinical...

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Bibliographic Details
Main Authors: Tong, Zhixiang, Martyn, Keir, Yang, Andy, Yin, Xiaolei, Mead, Benjamin E, Joshi, Nitin, Sherman, Nicholas E, Langer, Robert S, Karp, Jeffrey M
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134688