Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries

Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries

© 2017 Elsevier Ltd Successful antibody development requires both functional binding and desirable biophysical characteristics. In the current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, or nonspecificity. We used a high-throughput nonspecificity assay...

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Bibliographic Details
Main Authors: Kelly, Ryan L, Le, Doris, Zhao, Jessie, Wittrup, K Dane
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/134710

Internet

https://hdl.handle.net/1721.1/134710

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