High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing

High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing

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DNA polymerase fidelity is affected by both intrinsic properties and environmental conditions. Current strategies for measuring DNA polymerase error rate in vitro are constrained by low error subtype sensitivity, poor scalability, and lack of flexibility in types of sequence contexts that can be tes...

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Bibliographic Details
Main Authors: de Paz, Alexandra M, Cybulski, Thaddeus R, Marblestone, Adam H, Zamft, Bradley M, Church, George M, Boyden, Edward S, Kording, Konrad P, Tyo, Keith EJ
Format: Article
Language:English
Published: Oxford University Press (OUP) 2021
Online Access:https://hdl.handle.net/1721.1/134975

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https://hdl.handle.net/1721.1/134975

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