Optimization of Grignard Addition to Esters: Kinetic and Mechanistic Study of Model Phthalide Using Flow Chemistry

Optimization of Grignard Addition to Esters: Kinetic and Mechanistic Study of Model Phthalide Using Flow Chemistry

© 2018 American Chemical Society. The kinetics of sequential addition of a distinct Grignard species onto a lactone is studied by flow chemistry. The experimental data are shown to be consistent with a kinetic model based on four reaction steps, reaction of ester to magnesium hemiacetal, rearrangeme...

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Bibliographic Details
Main Authors: Pedersen, Michael J, Born, Stephen, Neuenschwander, Ulrich, Skovby, Tommy, Mealy, Michael J, Kiil, Søren, Dam-Johansen, Kim, Jensen, Klavs F
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: American Chemical Society (ACS) 2021
Online Access:https://hdl.handle.net/1721.1/135019

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https://hdl.handle.net/1721.1/135019

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