CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

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© 2019, The Author(s). Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing. Yet, the mechanisms underlyi...

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Bibliographic Details
Main Authors: Krajewska, Malgorzata, Dries, Ruben, Grassetti, Andrew V, Dust, Sofia, Gao, Yang, Huang, Hao, Sharma, Bandana, Day, Daniel S, Kwiatkowski, Nicholas, Pomaville, Monica, Dodd, Oliver, Chipumuro, Edmond, Zhang, Tinghu, Greenleaf, Arno L, Yuan, Guo-Cheng, Gray, Nathanael S, Young, Richard A, Geyer, Matthias, Gerber, Scott A, George, Rani E
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/135185

Internet

https://hdl.handle.net/1721.1/135185

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