Targeting the cyclin-dependent kinase 5 in metastatic melanoma

Targeting the cyclin-dependent kinase 5 in metastatic melanoma

© 2020 National Academy of Sciences. All rights reserved. The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5...

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Bibliographic Details
Main Authors: Sharma, Samanta, Zhang, Tian, Michowski, Wojciech, Rebecca, Vito W, Xiao, Min, Ferretti, Roberta, Suski, Jan M, Bronson, Roderick T, Paulo, Joao A, Frederick, Dennie, Fassl, Anne, Boland, Genevieve M, Geng, Yan, Lees, Jacqueline A, Medema, Rene H, Herlyn, Meenhard, Gygi, Steven P, Sicinski, Piotr
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/135192

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https://hdl.handle.net/1721.1/135192

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