PTCD1 is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease

PTCD1 is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease

In addition to amyloid-[1] plaques and tau tangles, mitochondrial dysfunction is implicated in the pathology of Alzheimer’s disease (AD). Neurons heavily rely on mitochondrial function, and deficits in brain energy metabolism are detected early in AD; however, direct human genetic evidence for mitoc...

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Bibliographic Details
Main Authors: Fleck, Daniel, Phu, Lilian, Verschueren, Erik, Hinkle, Trent, Reichelt, Mike, Bhangale, Tushar, Haley, Benjamin, Wang, Yuanyuan, Graham, Robert, Kirkpatrick, Donald S, Sheng, Morgan, Bingol, Baris
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Society for Neuroscience 2021
Online Access:https://hdl.handle.net/1721.1/135206

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https://hdl.handle.net/1721.1/135206

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