Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease

© 2020 National Academy of Sciences. All rights reserved. ClpA is a hexameric double-ring AAA+ unfoldase/translocase that functions with the ClpP peptidase to degrade proteins that are damaged or unneeded. How the 12 ATPase active sites of ClpA, 6 in the D1 ring and 6 in the D2 ring, work together t...

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Bibliographic Details
Main Authors: Zuromski, Kristin L, Sauer, Robert T, Baker, Tania A
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/135226