A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation fo...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2022
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| Online Access: | https://hdl.handle.net/1721.1/135273.2 |
| _version_ | 1810987556841455616 |
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| author | Sinnott-Armstrong, Nasa Sousa, Isabel S. Laber, Samantha Rendina-Ruedy, Elizabeth Nitter Dankel, Simon E. Ferreira, Teresa Mellgren, Gunnar Karasik, David Rivas, Manuel Pritchard, Jonathan Guntur, Anyonya R. Cox, Roger D. Lindgren, Cecilia M. Hauner, Hans Sallari, Richard Rosen, Clifford J. Hsu, Yi-Hsiang Lander, Eric S. Kiel, Douglas P. Claussnitzer, Melina |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sinnott-Armstrong, Nasa Sousa, Isabel S. Laber, Samantha Rendina-Ruedy, Elizabeth Nitter Dankel, Simon E. Ferreira, Teresa Mellgren, Gunnar Karasik, David Rivas, Manuel Pritchard, Jonathan Guntur, Anyonya R. Cox, Roger D. Lindgren, Cecilia M. Hauner, Hans Sallari, Richard Rosen, Clifford J. Hsu, Yi-Hsiang Lander, Eric S. Kiel, Douglas P. Claussnitzer, Melina |
| author_sort | Sinnott-Armstrong, Nasa |
| collection | MIT |
| description | Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture. |
| first_indexed | 2024-09-23T11:52:00Z |
| format | Article |
| id | mit-1721.1/135273.2 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:52:00Z |
| publishDate | 2022 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/135273.22024-06-14T18:45:37Z A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density Sinnott-Armstrong, Nasa Sousa, Isabel S. Laber, Samantha Rendina-Ruedy, Elizabeth Nitter Dankel, Simon E. Ferreira, Teresa Mellgren, Gunnar Karasik, David Rivas, Manuel Pritchard, Jonathan Guntur, Anyonya R. Cox, Roger D. Lindgren, Cecilia M. Hauner, Hans Sallari, Richard Rosen, Clifford J. Hsu, Yi-Hsiang Lander, Eric S. Kiel, Douglas P. Claussnitzer, Melina Massachusetts Institute of Technology. Department of Biology Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture. 2022-04-04T19:54:55Z 2021-10-27T20:22:44Z 2022-04-04T19:54:55Z 2021-03 2019-11 2021-07-20T18:04:37Z Article http://purl.org/eprint/type/JournalArticle 1550-4131 https://hdl.handle.net/1721.1/135273.2 en http://dx.doi.org/10.1016/j.cmet.2021.01.001 Cell Metabolism Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/octet-stream Elsevier BV Elsevier |
| spellingShingle | Sinnott-Armstrong, Nasa Sousa, Isabel S. Laber, Samantha Rendina-Ruedy, Elizabeth Nitter Dankel, Simon E. Ferreira, Teresa Mellgren, Gunnar Karasik, David Rivas, Manuel Pritchard, Jonathan Guntur, Anyonya R. Cox, Roger D. Lindgren, Cecilia M. Hauner, Hans Sallari, Richard Rosen, Clifford J. Hsu, Yi-Hsiang Lander, Eric S. Kiel, Douglas P. Claussnitzer, Melina A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_full | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_fullStr | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_full_unstemmed | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_short | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| title_sort | regulatory variant at 3q21 1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density |
| url | https://hdl.handle.net/1721.1/135273.2 |
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