A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation fo...
Main Authors: | Sinnott-Armstrong, Nasa, Sousa, Isabel S., Laber, Samantha, Rendina-Ruedy, Elizabeth, Nitter Dankel, Simon E., Ferreira, Teresa, Mellgren, Gunnar, Karasik, David, Rivas, Manuel, Pritchard, Jonathan, Guntur, Anyonya R., Cox, Roger D., Lindgren, Cecilia M., Hauner, Hans, Sallari, Richard, Rosen, Clifford J., Hsu, Yi-Hsiang, Lander, Eric S., Kiel, Douglas P., Claussnitzer, Melina |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | English |
Published: |
Elsevier BV
2022
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Online Access: | https://hdl.handle.net/1721.1/135273.2 |
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