USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels
Mutations or altered protein levels of SHANK3 are implicated in neurodevelopmental disorders such as Phelan–McDermid syndrome, autism spectrum disorders, and schizophrenia (Guilmatre et al., 2014). Loss of SHANK3 in mouse models results in decreased synapse density and reduction in the levels of mul...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Society for Neuroscience
2021
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| Online Access: | https://hdl.handle.net/1721.1/135298 |