A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution

A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution

© 2020, The Author(s). Aneuploidy is a feature of many cancers. Recent studies demonstrate that in the hematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells have reduced fitness and are efficiently purged from the bone marrow. However, early phases of hematopoietic reconstitution...

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Bibliographic Details
Main Authors: Rozhok, Andrii I, Silberman, Rebecca E, Higa, Kelly C, Liggett, L Alex, Amon, Angelika, DeGregori, James
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/135466

Internet

https://hdl.handle.net/1721.1/135466

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