Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

© 2020, The Author(s). Genetic variation can predispose to disease both through (i) monogenic risk variants that disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that involves many variants of small effect in different pathways. Few studies have explored the interpl...

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Bibliographic Details
Main Authors: Fahed, Akl C, Wang, Minxian, Homburger, Julian R, Patel, Aniruddh P, Bick, Alexander G, Neben, Cynthia L, Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T, Cassa, Christopher A, Lebo, Matthew, Ng, Kenney, Lander, Eric S, Zhou, Alicia Y, Kathiresan, Sekar, Khera, Amit V
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/135480

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https://hdl.handle.net/1721.1/135480

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