Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

<jats:p>Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low pr...

Full description

Bibliographic Details
Main Authors: Sánchez-Rivera, Francisco J, Ryan, Jeremy, Soto-Feliciano, Yadira M, Clare Beytagh, Mary, Xuan, Lucius, Feldser, David M, Hemann, Michael T, Zamudio, Jesse, Dimitrova, Nadya, Letai, Anthony, Jacks, Tyler
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/135549

Internet

https://hdl.handle.net/1721.1/135549

Similar Items