Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration
<jats:p>Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low pr...
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Proceedings of the National Academy of Sciences
2021
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| Online Access: | https://hdl.handle.net/1721.1/135549 |