Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

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Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...

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Bibliographic Details
Main Authors: Nguyen, Tam NT, Sha, Sha, Hong, Moo Sun, Maloney, Andrew J, Barone, Paul W, Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L, Sinskey, Anthony J, Braatz, Richard D
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/135559

Internet

https://hdl.handle.net/1721.1/135559

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