Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells

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Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...

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Bibliographic Details
Main Authors: Nguyen, Tam N.T., Sha, Sha, Hong, Moo Sun, Maloney, Andrew J., Barone, Paul W., Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L., Sinskey, Anthony J., Braatz, Richard D.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/135559.2

Internet

https://hdl.handle.net/1721.1/135559.2

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