Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...

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Bibliographic Details
Main Authors:	Nguyen, Tam NT, Sha, Sha, Hong, Moo Sun, Maloney, Andrew J, Barone, Paul W, Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L, Sinskey, Anthony J, Braatz, Richard D
Format:	Article
Language:	English
Published:	Elsevier BV 2021
Online Access:	https://hdl.handle.net/1721.1/135559

Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells by Nguyen, Tam N.T., Sha, Sha, Hong, Moo Sun, Maloney, Andrew J., Barone, Paul W., Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L., Sinskey, Anthony J., Braatz, Richard D.

Published 2022

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Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells

Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells by Nguyen, Tam N.T., Sha, Sha, Hong, Moo Sun, Maloney, Andrew J., Barone, Paul W., Neufeld, Caleb, Wolfrum, Jacqueline, Springs, Stacy L., Sinskey, Anthony J., Braatz, Richard D.

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