Mechanistic Model for Production of Recombinant Adeno-associated Virus via Triple Transfection of HEK293 Cells
Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains challenging, with low yields and low full:empty capsid ratios in the harvest. To elucidate the dynamics of recombinant viral production, we develop a mechanistic model for the synthesis of rAAV viral vectors by triple p...
| Κύριοι συγγραφείς: | , , , , , , , , , |
|---|---|
| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
Elsevier BV
2021
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| Διαθέσιμο Online: | https://hdl.handle.net/1721.1/135559 |
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