Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase

Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase

Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we present a 2.7 Å resolution X-ray structure of wild-type IslA fr...

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Bibliographic Details
Main Authors: Dawson, Christopher D, Irwin, Stephania M, Backman, Lindsey RF, Le, Chip, Wang, Jennifer X, Vennelakanti, Vyshnavi, Yang, Zhongyue, Kulik, Heather J, Drennan, Catherine L, Balskus, Emily P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/135563

Internet

https://hdl.handle.net/1721.1/135563

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