Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion

Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion

T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of autoimmunity, T cell exhaustion has been favorably correlated with long-term clinical outcome. Understanding the development of exhaustion in autoimmune settings may prov...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhu, Chen, Dixon, Karen O, Newcomer, Kathleen, Gu, Guangxiang, Xiao, Sheng, Zaghouani, Sarah, Schramm, Markus A, Wang, Chao, Zhang, Huiyuan, Goto, Kouichiro, Christian, Elena, Rangachari, Manu, Rosenblatt-Rosen, Orit, Okada, Hitoshi, Mak, Tak, Singer, Meromit, Regev, Aviv, Kuchroo, Vijay
Övriga upphovsmän: Massachusetts Institute of Technology. Department of Biology
Materialtyp: Artikel
Språk:English
Publicerad: American Association for the Advancement of Science (AAAS) 2021
Länkar:https://hdl.handle.net/1721.1/135600

Internet

https://hdl.handle.net/1721.1/135600

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