Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that regulate cell fate has rarely been defined. We discovered, using a chemical suppressor screen, that inhibition of the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenas...

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Bibliographic Details
Main Authors: Rossmann, Marlies P, Hoi, Karen, Chan, Victoria, Abraham, Brian J, Yang, Song, Mullahoo, James, Papanastasiou, Malvina, Wang, Ying, Elia, Ilaria, Perlin, Julie R, Hagedorn, Elliott J, Hetzel, Sara, Weigert, Raha, Vyas, Sejal, Nag, Partha P, Sullivan, Lucas B, Warren, Curtis R, Dorjsuren, Bilguujin, Greig, Eugenia Custo, Adatto, Isaac, Cowan, Chad A, Schreiber, Stuart L, Young, Richard A, Meissner, Alexander, Haigis, Marcia C, Hekimi, Siegfried, Carr, Steven A, Zon, Leonard I
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021
Online Access:https://hdl.handle.net/1721.1/135623

Internet

https://hdl.handle.net/1721.1/135623

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