Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals

Recent advances in high-throughput T cell receptor (TCR) sequencing have allowed for new insights into the human TCR repertoire. However, methods for capturing antigen-specific repertoires remain an area of development. Here, we describe a potentially novel approach that utilizes both a biological a...

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Bibliographic Details
Main Authors: Smith, Neal P, Ruiter, Bert, Virkud, Yamini V, Tu, Ang A, Monian, Brinda, Moon, James J, Love, J Christopher, Shreffler, Wayne G
Other Authors: Massachusetts Institute of Technology. Department of Physics
Format: Article
Language:English
Published: American Society for Clinical Investigation 2021
Online Access:https://hdl.handle.net/1721.1/135626