Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease

Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease

INTRODUCTION: Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) model for seven therapeutics: aducanumab, crene...

Full description

Bibliographic Details
Main Authors: Madrasi, Kumpal, Das, Raibatak, Mohmmadabdul, Hafiz, Lin, Lin, Hyman, Bradley T, Lauffenburger, Douglas A, Albers, Mark W, Rissman, Robert A, Burke, John M, Apgar, Joshua F, Wille, Lucia, Gruenbaum, Lore, Hua, Fei
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Wiley 2021
Online Access:https://hdl.handle.net/1721.1/135639

Internet

https://hdl.handle.net/1721.1/135639

Similar Items