Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease
INTRODUCTION: Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) model for seven therapeutics: aducanumab, crene...
Հիմնական հեղինակներ: | , , , , , , , , , , , , |
---|---|
Այլ հեղինակներ: | |
Ձևաչափ: | Հոդված |
Լեզու: | English |
Հրապարակվել է: |
Wiley
2021
|
Առցանց հասանելիություն: | https://hdl.handle.net/1721.1/135639 |