Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease
INTRODUCTION: Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) model for seven therapeutics: aducanumab, crene...
Main Authors: | Madrasi, Kumpal, Das, Raibatak, Mohmmadabdul, Hafiz, Lin, Lin, Hyman, Bradley T, Lauffenburger, Douglas A, Albers, Mark W, Rissman, Robert A, Burke, John M, Apgar, Joshua F, Wille, Lucia, Gruenbaum, Lore, Hua, Fei |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | English |
Published: |
Wiley
2021
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Online Access: | https://hdl.handle.net/1721.1/135639 |
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