DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization of spermatogenesis. W...

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Bibliographic Details
Main Authors: Mikedis, Maria M, Fan, Yuting, Nicholls, Peter K, Endo, Tsutomu, Jackson, Emily K, Cobb, Sarah A, de Rooij, Dirk G, Page, David C
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2021
Online Access:https://hdl.handle.net/1721.1/135996