H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect
© 2020 Elsevier Inc. Burkhart et al. show that mutants lacking components of H3.3 assembly complexes have pleiotropic defects that manifest near the onset of adulthood. Mitochondrial stress likely contributes to these late-onset defects. The late-onset defects of H3.3 assembly mutants can be materna...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/136022 |
| _version_ | 1811088541064626176 |
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| author | Burkhart, Kirk B Sando, Steven R Corrionero, Anna Horvitz, H Robert |
| author2 | Howard Hughes Medical Institute |
| author_facet | Howard Hughes Medical Institute Burkhart, Kirk B Sando, Steven R Corrionero, Anna Horvitz, H Robert |
| author_sort | Burkhart, Kirk B |
| collection | MIT |
| description | © 2020 Elsevier Inc. Burkhart et al. show that mutants lacking components of H3.3 assembly complexes have pleiotropic defects that manifest near the onset of adulthood. Mitochondrial stress likely contributes to these late-onset defects. The late-onset defects of H3.3 assembly mutants can be maternally rescued. |
| first_indexed | 2024-09-23T14:03:47Z |
| format | Article |
| id | mit-1721.1/136022 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:03:47Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1360222023-02-23T20:32:59Z H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect Burkhart, Kirk B Sando, Steven R Corrionero, Anna Horvitz, H Robert Howard Hughes Medical Institute Massachusetts Institute of Technology. Department of Biology © 2020 Elsevier Inc. Burkhart et al. show that mutants lacking components of H3.3 assembly complexes have pleiotropic defects that manifest near the onset of adulthood. Mitochondrial stress likely contributes to these late-onset defects. The late-onset defects of H3.3 assembly mutants can be maternally rescued. 2021-10-27T20:30:27Z 2021-10-27T20:30:27Z 2020 2021-07-16T15:40:38Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/136022 en 10.1016/J.CUB.2020.04.046 Current Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Burkhart, Kirk B Sando, Steven R Corrionero, Anna Horvitz, H Robert H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect |
| title | H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect |
| title_full | H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect |
| title_fullStr | H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect |
| title_full_unstemmed | H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect |
| title_short | H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect |
| title_sort | h3 3 nucleosome assembly mutants display a late onset maternal effect |
| url | https://hdl.handle.net/1721.1/136022 |
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