REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

© 2020 National Academy of Sciences. All rights reserved. REV1/POLζ-dependent mutagenic translesion synthesis (TLS) promotes cell survival after DNA damage but is responsible for most of the resulting mutations. A novel inhibitor of this pathway, JH-RE-06, promotes cisplatin efficacy in cancer cells...

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Bibliographic Details
Main Authors: Chatterjee, Nimrat, Whitman, Matthew A, Harris, Cynthia A, Min, Sophia M, Jonas, Oliver, Lien, Evan C, Luengo, Alba, Vander Heiden, Matthew G, Hong, Jiyong, Zhou, Pei, Hemann, Michael T, Walker, Graham C
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2021
Online Access:https://hdl.handle.net/1721.1/136057

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https://hdl.handle.net/1721.1/136057

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