Increased demand for NAD+ relative to ATP drives aerobic glycolysis

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many organisms and conditions. To better understand that association, we examined the metabolic consequence of activating the pyruvate dehydrogena...

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Bibliographic Details
Main Authors: Luengo, Alba, Li, Zhaoqi, Gui, Dan Y, Sullivan, Lucas B, Zagorulya, Maria, Do, Brian T, Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A, Thomas, Craig J, Spranger, Stefani, Matheson, Nicholas J, Vander Heiden, Matthew G
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/136078

Internet

https://hdl.handle.net/1721.1/136078

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