Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

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Advanced age and the APOE ϵ4 allele are the two biggest risk factors for Alzheimer's disease (AD) and declining cognitive function. Wedescribe a universal gauge to measuremolecular brain age using transcriptome analysis of four human postmortem cohorts (n = 673, ages 25-97) free of neurological...

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Bibliographic Details
Main Authors: Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P
Format: Article
Language:English
Published: Life Science Alliance, LLC 2021
Online Access:https://hdl.handle.net/1721.1/136105

Internet

https://hdl.handle.net/1721.1/136105

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