Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

Copyright © 2020 The Authors, some rights reserved. Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly understood. To reveal early steps in BRCA2-associated carcinogenesis, we analyzed sorted cel...

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Bibliographic Details
Main Authors: Karaayvaz-Yildirim, Mihriban, Silberman, Rebecca E, Langenbucher, Adam, Saladi, Srinivas Vinod, Ross, Kenneth N, Zarcaro, Elena, Desmond, Andrea, Yildirim, Murat, Vivekanandan, Varunika, Ravichandran, Hiranmayi, Mylavagnanam, Ravindra, Specht, Michelle C, Ramaswamy, Sridhar, Lawrence, Michael, Amon, Angelika, Ellisen, Leif W
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2021
Online Access:https://hdl.handle.net/1721.1/136226

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https://hdl.handle.net/1721.1/136226

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