RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

© 2020, The Author(s), under exclusive licence to Springer Nature Limited. The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates the e...

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Bibliographic Details
Main Authors: Santoriello, Cristina, Sporrij, Audrey, Yang, Song, Flynn, Ryan A, Henriques, Telmo, Dorjsuren, Bilguujin, Custo Greig, Eugenia, McCall, Wyatt, Stanhope, Meredith E, Fazio, Maurizio, Superdock, Michael, Lichtig, Asher, Adatto, Isaac, Abraham, Brian J, Kalocsay, Marian, Jurynec, Michael, Zhou, Yi, Adelman, Karen, Calo, Eliezer, Zon, Leonard I
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/136227

Internet

https://hdl.handle.net/1721.1/136227

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