Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

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© 2020 The Authors Thompson et al. describe a cyclin D1+ neural stem cell population unique to adult-onset Huntington's disease iPSC-derived neuronal cultures, differentiated using a protocol that increases the derivation of medium spiny neurons. These findings highlight a selective CAG-length-...

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Bibliographic Details
Main Authors: Smith-Geater, Charlene, Hernandez, Sarah J, Lim, Ryan G, Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T, Wassie, Brook T, Gold, Maxwell Philip, Wang, Keona Q, Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J, Allen, Nicholas D, Fraenkel, Ernest, Thompson, Leslie M
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/136240

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https://hdl.handle.net/1721.1/136240

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