Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

Genome-wide association studies have associated thousands of genetic variants with complex traits and diseases, but pinpointing the causal variant(s) among those in tight linkage disequilibrium with each associated variant remains a major challenge. Here, we use seven experimental assays to characte...

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Bibliographic Details
Main Authors: Ray, John P, de Boer, Carl G, Fulco, Charles P, Lareau, Caleb A, Kanai, Masahiro, Ulirsch, Jacob C, Tewhey, Ryan, Ludwig, Leif S, Reilly, Steven K, Bergman, Drew T, Engreitz, Jesse M, Issner, Robbyn, Finucane, Hilary K, Lander, Eric S, Regev, Aviv, Hacohen, Nir
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/136246

Internet

https://hdl.handle.net/1721.1/136246

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