Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

© 2020 Elsevier Inc. Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening has not been possible to perform in the mammalian central nervous system (CNS). Here, we report the results of the first genome-wide genetic screens in...

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Detalhes bibliográficos
Principais autores: Wertz, Mary H, Mitchem, Mollie R, Pineda, S Sebastian, Hachigian, Lea J, Lee, Hyeseung, Lau, Vanessa, Powers, Alex, Kulicke, Ruth, Madan, Gurrein K, Colic, Medina, Therrien, Martine, Vernon, Amanda, Beja-Glasser, Victoria F, Hegde, Mudra, Gao, Fan, Kellis, Manolis, Hart, Traver, Doench, John G, Heiman, Myriam
Outros Autores: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Formato: Artigo
Idioma:English
Publicado em: Elsevier BV 2021
Acesso em linha:https://hdl.handle.net/1721.1/136278

Internet

https://hdl.handle.net/1721.1/136278

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