MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs

© 2019 Elsevier Inc. MicroRNAs (miRNAs) specify the recruitment of deadenylases to mRNA targets. Despite this recruitment, we find that miRNAs have almost no effect on steady-state poly(A)-tail lengths of their targets in mouse fibroblasts, which motivates the acquisition of pre-steady-state measure...

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Bibliographic Details
Main Authors: Eisen, Timothy Jonas, Eichhorn, Stephen William, Subtelny, Alexander Orest, Bartel, David
Other Authors: Howard Hughes Medical Institute
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/136297.2