Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

A high-throughput method for amplication-free single-cell whole-genome sequencing can be scaled up to analyze tens of thousands of cells from different tissues and clinical sample types and identifies replication states, aneuploidies, and subclonal mutations.

Bibliographic Details
Main Author: Boyden, Edward
Other Authors: Massachusetts Institute of Technology. Media Laboratory
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/136528.2