In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

© 2019 Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subunit of the translation initiation factor eIF3 in the...

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Bibliographic Details
Main Authors: Smekalova, Elena M, Gerashchenko, Maxim V, O’Connor, Patrick BF, Whittaker, Charles A, Kauffman, Kevin J, Fefilova, Anna S, Zatsepin, Timofei S, Bogorad, Roman L, Baranov, Pavel V, Langer, Robert, Gladyshev, Vadim N, Anderson, Daniel G, Koteliansky, Victor
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/136581

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https://hdl.handle.net/1721.1/136581

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