Reconstructing continuous distributions of 3D protein structure from cryo-EM images

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution. In single particle cryo-EM, the central problem is to reconstruct the three-dimensional structure of a macromolecule from $10^{4-7}$ n...

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Bibliographic Details
Main Authors: Zhong, Ellen D, Bepler, Tristan, Davis, Joseph H, Berger, Bonnie
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: 2021
Online Access:https://hdl.handle.net/1721.1/137001