Decreasing mitochondrial RNA polymerase activity reverses biased inheritance of hypersuppressive mtDNA

Decreasing mitochondrial RNA polymerase activity reverses biased inheritance of hypersuppressive mtDNA

<jats:p>Faithful inheritance of mitochondrial DNA (mtDNA) is crucial for cellular respiration/oxidative phosphorylation and mitochondrial membrane potential. However, how mtDNA is transmitted to progeny is not fully understood. We utilized hypersuppressive mtDNA, a class of respiratory deficie...

Full description

Bibliographic Details
Main Authors: Corbi, Daniel, Amon, Angelika
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021
Online Access:https://hdl.handle.net/1721.1/138121

Internet

https://hdl.handle.net/1721.1/138121

Similar Items