Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis
© 2020 The Authors Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Fi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/138269 |
| _version_ | 1826203135807324160 |
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| author | Roussarie, Jean-Pierre Yao, Vicky Rodriguez-Rodriguez, Patricia Oughtred, Rose Rust, Jennifer Plautz, Zakary Kasturia, Shirin Albornoz, Christian Wang, Wei Schmidt, Eric F Dannenfelser, Ruth Tadych, Alicja Brichta, Lars Barnea-Cramer, Alona Heintz, Nathaniel Hof, Patrick R Heiman, Myriam Dolinski, Kara Flajolet, Marc Troyanskaya, Olga G Greengard, Paul |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Roussarie, Jean-Pierre Yao, Vicky Rodriguez-Rodriguez, Patricia Oughtred, Rose Rust, Jennifer Plautz, Zakary Kasturia, Shirin Albornoz, Christian Wang, Wei Schmidt, Eric F Dannenfelser, Ruth Tadych, Alicja Brichta, Lars Barnea-Cramer, Alona Heintz, Nathaniel Hof, Patrick R Heiman, Myriam Dolinski, Kara Flajolet, Marc Troyanskaya, Olga G Greengard, Paul |
| author_sort | Roussarie, Jean-Pierre |
| collection | MIT |
| description | © 2020 The Authors Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability. |
| first_indexed | 2024-09-23T12:31:55Z |
| format | Article |
| id | mit-1721.1/138269 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:31:55Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1382692023-12-06T21:53:25Z Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis Roussarie, Jean-Pierre Yao, Vicky Rodriguez-Rodriguez, Patricia Oughtred, Rose Rust, Jennifer Plautz, Zakary Kasturia, Shirin Albornoz, Christian Wang, Wei Schmidt, Eric F Dannenfelser, Ruth Tadych, Alicja Brichta, Lars Barnea-Cramer, Alona Heintz, Nathaniel Hof, Patrick R Heiman, Myriam Dolinski, Kara Flajolet, Marc Troyanskaya, Olga G Greengard, Paul Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory © 2020 The Authors Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability. 2021-12-01T15:49:42Z 2021-12-01T15:49:42Z 2020 2021-12-01T15:47:36Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/138269 Roussarie, Jean-Pierre, Yao, Vicky, Rodriguez-Rodriguez, Patricia, Oughtred, Rose, Rust, Jennifer et al. 2020. "Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis." Neuron, 107 (5). en 10.1016/J.NEURON.2020.06.010 Neuron Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Roussarie, Jean-Pierre Yao, Vicky Rodriguez-Rodriguez, Patricia Oughtred, Rose Rust, Jennifer Plautz, Zakary Kasturia, Shirin Albornoz, Christian Wang, Wei Schmidt, Eric F Dannenfelser, Ruth Tadych, Alicja Brichta, Lars Barnea-Cramer, Alona Heintz, Nathaniel Hof, Patrick R Heiman, Myriam Dolinski, Kara Flajolet, Marc Troyanskaya, Olga G Greengard, Paul Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis |
| title | Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis |
| title_full | Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis |
| title_fullStr | Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis |
| title_full_unstemmed | Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis |
| title_short | Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis |
| title_sort | selective neuronal vulnerability in alzheimer s disease a network based analysis |
| url | https://hdl.handle.net/1721.1/138269 |
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