High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately leading to cell death (tauopathy). Recently, a...

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Bibliographic Details
Main Authors: Cheng, Chialin, Reis, Surya A, Adams, Emily T, Fass, Daniel M, Angus, Steven P, Stuhlmiller, Timothy J, Richardson, Jared, Olafson, Hailey, Wang, Eric T, Patnaik, Debasis, Beauchamp, Roberta L, Feldman, Danielle A, Silva, M Catarina, Sur, Mriganka, Johnson, Gary L, Ramesh, Vijaya, Miller, Bruce L, Temple, Sally, Kosik, Kenneth S, Dickerson, Bradford C, Haggarty, Stephen J
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2021
Online Access:https://hdl.handle.net/1721.1/138330

Internet

https://hdl.handle.net/1721.1/138330

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