APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

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The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer's disease (AD). One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated pathology in neurons such as amyloid-β (Aβ) accumulatio...

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Bibliographic Details
Main Authors: Lee, Se-In, Jeong, Woojin, Lim, Heejin, Cho, Sukhee, Lee, Hyein, Jang, Yonghee, Cho, Joonho, Bae, Simsung, Lin, Yuan-Ta, Tsai, Li-Huei, Moon, Dae Won, Seo, Jinsoo
Format: Article
Language:English
Published: Elsevier BV 2021
Online Access:https://hdl.handle.net/1721.1/138381

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https://hdl.handle.net/1721.1/138381

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