New tools for the discovery of pigment gene function

Dozens of genes contribute to the vast variation in human pigmentation. Many of these encode proteins that localize to the melanosome, the lysosome-related organelle that synthesizes pigment, but have unclear functions. Here, we describe the MelanoIP method for rapidly isolating melanosomes and prof...

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Bibliographic Details
Main Author: Adelmann, Charles H.
Other Authors: Sabatini, David M.
Format: Thesis
Published: Massachusetts Institute of Technology 2022
Online Access:https://hdl.handle.net/1721.1/139443