Model‐based control for column‐based continuous viral inactivation of biopharmaceuticals

Batch low-pH hold is a common processing step to inactivate enveloped viruses for biologics derived from mammalian sources. Increased interest in the transition of biopharmaceutical manufacturing from batch to continuous operation resulted in numerous attempts to adapt batch low-pH hold to continuou...

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Bibliographic Details
Main Authors: Hong, Moo Sun, Lu, Amos E., Ou, Rui Wen, Wolfrum, Jacqueline M., Springs, Stacy L., Sinskey, Anthony J., Braatz, Richard D.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Wiley 2022
Online Access:https://hdl.handle.net/1721.1/140434